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KMID : 0545120090190070681
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 7 p.681 ~ p.684
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Isolation of 1’,3’-Dilinolenoyl’-2’-Linoleoylglycerol with Tyrosinase Inhibitory Activity from Flammulina velutipes
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Jang Se-Gul
Jeon Kyung-Su
Lee Eun-Hee
Kong Won-Sik
Cho Jae-Yong
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Abstract
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This study was carried out to evaluate the inhibitory effect of Flammulina velutipes extracts on tyrosinase activity and to identify its biologically active component. The ethyl acetate and n-butanol extracts showed potent tyrosinase inhibitory activities. Subsequently, fractions of the nbutanol extract showed only a partial tyrosinase inhibitory activity. The most active compound of tyrosinase inhibitory activity was identified from the ethyl acetate extract as 1’,3’-dilinolenoyl-2’-linoleoylglycerol (LnLLn) by comparing its mass, 1H-, and 13C-NMR spectral data with those previously reported in the literature. LnLLn showed tyrosinase inhibitory activity with an IC50 value of 16.1 μg/ml. These results suggest that the ethyl acetate extract of F. velutipes could be applicable for the development of a new whitening agent.
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KEYWORD
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1’, 3’-Dilinolenoyl-2’-linoleoylglycerol (LnLLn), Flammulina velutipes, tyrosinase inhibitory activity, whitening effect
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